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A randomized controlled study comparing fluoroquinolone based sequential therapy versus clarithromycin triple therapy for the eradication of helicobacter pylori in Egypt / Ibrahim Mohamed Ibrahim Naguib ; Supervised Iman Mohamed Hamza , Waleed Fouad Fathalah , Walied Khalid Alhossary

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ibrahim Mohamed Ibrahim Naguib , 2019Description: 104 P. : charts , facsimiles ; 25cmOther title:
  • تجربة عشوائية لمقارنة العلاج التسلسلى المشتمل على الفلوروكينولون و العلاج الثلاثى الكلاسيكى المشتمل على الكلاريثروميسين فى القضاء على البكتيريا الحلزونية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Aim: This study aimed at evaluating Moxifloxacin-based sequential therapy VS. Clarithromycin triple therapy as first line regimens for eradication of H-pylori. Methods: In this randomized clinical trial, 93 HP infected patients were randomly divided into two groups. Moxifloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7 days followed by omeprazole, metronidazole and moxifloxacin for 7days.Clarithromycin based triple regimen (group B): omeprazole, amoxicillin and clarithromycin for 14days. Stool antigen test was used to evaluate HP eradication 6 weeks after the end of treatment.Compliance, drug side effects and dypepsia improvement were secondary outcomes.Results: Per protocol eradication rates of group A and B were 79.5% and 86% respectively. By intention to treat analysis, group A had an eradication rate of 68.9% while group B had an eradication rate of 77.1%. Conclusion: In this study,Triple therapy was more effective than moxifloxacin-sequential therapy. However, the difference was statistically insignificant. Studies with larger sample size are needed
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2019.Ib.R (Browse shelf(Opens below)) Not for loan 01010110080581000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2019.Ib.R (Browse shelf(Opens below)) 80581.CD Not for loan 01020110080581000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Aim: This study aimed at evaluating Moxifloxacin-based sequential therapy VS. Clarithromycin triple therapy as first line regimens for eradication of H-pylori. Methods: In this randomized clinical trial, 93 HP infected patients were randomly divided into two groups. Moxifloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7 days followed by omeprazole, metronidazole and moxifloxacin for 7days.Clarithromycin based triple regimen (group B): omeprazole, amoxicillin and clarithromycin for 14days. Stool antigen test was used to evaluate HP eradication 6 weeks after the end of treatment.Compliance, drug side effects and dypepsia improvement were secondary outcomes.Results: Per protocol eradication rates of group A and B were 79.5% and 86% respectively. By intention to treat analysis, group A had an eradication rate of 68.9% while group B had an eradication rate of 77.1%. Conclusion: In this study,Triple therapy was more effective than moxifloxacin-sequential therapy. However, the difference was statistically insignificant. Studies with larger sample size are needed

Issued also as CD

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