Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology

Background: Glycometabolic disturbances are linked with increased morbidity and mortality in patients with acute coronary syndrome (ACS) [1]. They are independent predictors of future cardiovascular complications in patients with ACS, irrespective of their diabetic status [2, 3]. Glucose variability (GV) is one component of glycometabolic disturbance that mirrors blood glucose fluctuations throughout the day or even longer. Increased GV carries a significant risk of short-term and long-term adverse outcomes [4, 5] and is associated with a longer hospital stay, infections, and in-hospital mortality [6, 7]. objectives To assess relation between GV and occurrence of MI, HF, recurrent chest pain and mortality after 3 months follow up. materials & methods The current study was a prospective observational study. It included 166 patients without known diabetes mellitus patients admitted to ICU or CCU in Heliopolis hospital with their first attack of ACS during the period from May 2019 till February 2020. Inclusion criteria: Age >18 yrs Non Diabetic patients. Patients presented with their 1st attack of ACS including STEMI NSTEMI Unstable angina .Exclusion criteria: DM patients: Patients with previous myocardial infarction. Patients with a history of a previous percutaneous intervention. Patients with a history of CABG. results Follow up after three months revealed significant difference between group (I) & group (II) as regards MI (p < 0.001), heart failure (p < 0.001) & recurrent chest pain (p < 0.001) but not with mortality (p 0.428) ( Table 5 )

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