Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anesthesia

Background: Various drugs are used for providing favorable intubation conditions during awake fiberoptic intubation (AFOI). However, most of them have various side effects. Aim: The aim of this study was to compare the effects of dexmedetomedine , magnesium sulphate and fentanyl as regards sedative effects , hemodynamic stability, intubation time and intubation attempts during awake fiberoptic intubation. Material and Methods: A randomized double-blind prospective study was conducted on a total of 60 patients scheduled for elective cervical spine surgeries who were randomly allocated into three equal groups (n 20): group A patients received a bolus dose of dexmedetomidine of 1 mcg/kg over 10 min followed by a continuous infusion of dexmedetomidine at 0.5 mcg/kg/h., Magnesium sulphate group (group B) received dose of 30mg/kg over 10 min followed by 10mg/kg/hr. and fentanyl group (group c) received dose of 1 og/kg over 10 min followed by 0.5 og/kg/hr. Sedation score (Ramsy sedation score), hemodynamic variables, oxygen saturation, intubation time and intubation attempts were noted and compared between three groups. Results: RSS was significantly favorable (P < 0.001) in group A in comparison to group B and C , moreover better hemodynamic stability during intubation (P < 0.05) and less intubation attempts was observed in group A in comparison to the other two groups

Issued also as CD