Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

During the last decades, Acinetobacter baumannii become a global problem that threatens many health care settings. A. bammunnii is characterized by its extraordinary ability to persist in the environment. Moreover, it has a magnificence ability to acquire and express multiple resistance mechanisms against major antibiotic classes. There is no unique bacterial metabolic test that can differentiate it from other non - lactose fermenter gram negative bacteria; furthermore, the pathogenicity of Acinetobacter species is not the same. A. baumannii species are the most frequently involved in severe infections. The present study aimed to characterize the prevalence of MDR - A. bammunnii in Egyptian hospital; Identify their antimicrobial susceptibility level; phenotypic characterization of resistance mechanisms; molecular identification of class D and metallo - Ý - lactamase; molecular typing of IMRAB and apply nano - gold assay using unmodified AuNPs for rapid detection of A. baummnnii

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