Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Introduction: The prevalence of Metabolic Syndrome is increasing worldwide and associated with an increased risk of cardiovascular disease, meanwhile the use of ionizing radiation might be considered a two-edged sword as it has high benefits as well as dangerous harmful effects on human beings. Aim of work: This study is designed to determine the therapeutic effect of Lisinopril in minimizing radiation-induced injuries in rats with fructose induced metabolic syndrome. Study Design: Rats were divided into 7 groups, each consisting of 15 rats. Control (CTR) animals had free access to ordinary tap water, Radiation (RAD) animals exposed to total body gamma irradiation of 1 GY every 4 weeks starting from week zero up to week 20, Fructose (FRC) animals provided with 10% fructose solution to drink ad libitum for 20 weeks, Radiation Fructose (RF) animals exposed to total body gamma irradiation of 1 GY every 4 weeks starting from week zero up to week 20 and provided with 10% fructose solution ad libitum for 20 weeks. Lisinopril (LIS) treated groups were administered 10mg/kg/day orally during the last 4 weeks of the experiment (week 17-20). Parameters measured: Systolic blood pressure, Body weight gain, Glucose levels, Insulin levels, Insulin resistance, Insulin sensitivity, ß-cell function, Intraperitoneal glucose tolerance test, Triglycerides, Total cholesterol, High density lipoproteins, Very low density lipoproteins, Low density lipoproteins, TG/HDL ratio, TC/HDL ratio, Thiobarbituric acid reactive substances, Reduced Glutathione (GSH), Uric acid, Creatinine, Alanine aminotransferase (ALT) activity and Aspartate aminotransferase (AST) activity, Interleukin-1beta (IL-1Ý) and tumor necrosis factor alfa (TNF-Ü)

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