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Analytical study for tadalafil (Cialis®) and equivalent compounds / Moataz Abdalla Yehia ; Supervised Mohamed Abdelkawy Ibrahim , Mohamed Abdalla Elsayed , Mamdouh Reda Rezk

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Moataz Abdalla Yehia , 2015Description: 211 P. : charts ; 25cmOther title:
  • دراسة تحليلية للتادالافيل (سيالس) و بعض المركبات الشبيهه [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry Summary: Four different stability indicating assay methods were developed and validated for the determination of (tadalafil, sildenafil and terazosin) in the presence of its degradation product. The first and second methods was based on the derivative and derivative ratio spectrophotometric technique using acetonitrile: water mixtrure {u2160}:{u2160} for tadalafil and methanol as a solvent for both sildenafil and terazosin. In the third method, we used TLC - densitometric technique using high performance thin - layer chromatography plates with a developing system consisting of {chloroform: acetone: ammonia (9: 1: 0.1, by volume)}, {chloroform: toluene: ethanol: acetic acid(3: 3: 4: 0.1, by volume)} and choloroform: acetone: ammonia 6: 4: 0.1, by voiumes
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.M.Sc.2015.Mo.A (Browse shelf(Opens below)) Not for loan 01010110066811000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.03.M.Sc.2015.Mo.A (Browse shelf(Opens below)) 66811.CD Not for loan 01020110066811000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

Four different stability indicating assay methods were developed and validated for the determination of (tadalafil, sildenafil and terazosin) in the presence of its degradation product. The first and second methods was based on the derivative and derivative ratio spectrophotometric technique using acetonitrile: water mixtrure {u2160}:{u2160} for tadalafil and methanol as a solvent for both sildenafil and terazosin. In the third method, we used TLC - densitometric technique using high performance thin - layer chromatography plates with a developing system consisting of {chloroform: acetone: ammonia (9: 1: 0.1, by volume)}, {chloroform: toluene: ethanol: acetic acid(3: 3: 4: 0.1, by volume)} and choloroform: acetone: ammonia 6: 4: 0.1, by voiumes

Issued also as CD

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