Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Orthopedic Surgery

Background: Surgical site infection, especially in surgeries for musculoskeletal tumors, poses a considerable challenge for the orthopedic surgeon. The challenge stems from the high incidence of infection complications encountered after the reconstruction methods include allografts, tumor endoprostheses, and allograft-prosthetic composites. Aim: To evaluate the effectiveness and difference of short duration and long duration antibiotic prophylaxis in minimizing infection rate after bone and soft tissue tumor surgery. Materials and methods: A prospective randomized control trial study was conducted involving 76 patients divided into two groups. Each group divided into two subgroups; subgroups of benign tumor group (B group) and subgroups of malignant tumor (M group). The patients received preoperative prophylactic antibiotic dose of cefoperazone-sulbactam and re-dosing in case of blood transfusion or / with operative duration exceeding 3 hours, and then received postoperative doses of cefoperazone-sulbactam according to randomly selected groups and patients clinically followed-up for three months postoperatively

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