Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Background: Pulmonary hypertension (PH) has been reported with increasing frequency in patients with overt hyperthyroidism. Because studies with a limited number of patients have looked into the association between hyperthyroidism and elevated pulmonary artery pressure, we designed a study to determine the prevalence of pulmonary hypertension in patients with thyrotoxicosis and the clinical characteristics of these patients.Objectives: we designed a study to determine the prevalence of pulmonary hypertension in patients with thyrotoxicosis and the clinical characteristics of these patients.Methods: we study the prevalence of pulmonary hypertension among eighty five Egyptian patients with uncontrolled primary hyperthyroidism recruited from the endocrinology clinic and internal medicine department and trying to find a pathogenetic link between both conditions. Results: In this study we found that the prevalence of pulmonary hypertension among patients with uncontrolled primary hyperthyroidism to be at a rate of 19.7 % and that there is an autoimmune pathogenetic link between hyperthyroidism and development of pulmonary hypertension. Conclusion: the prevalence of pulmonary hypertension among patients with uncontrolled primary hyperthyroidism is at a rate of 19.7 %. hyperthyroidism should always be considered in the differential diagnosis of a patient presenting with pulmonary hypertension

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