Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

According to (WHO) one in every four couples had been found to be affected by infertility in developing countries, with estimated number of more than 186 million ever-married women of reproductive age were maintaining a "child wish". Infertility means not being able to conceive after one year of regular unprotected sex, or six months if a woman is 35 years old or older.It constitutes a major social and psychological burden amongst couples, and the prevalence is increasing.The primary goal of assisted reproductive technology (ART) is the birth of a healthy child. This outcome depends on a multitude of non-mutual independent factors, including female age and the effect of ovarian stimulation (OS).The number of oocytes retrieved after OS represents a critical cornerstone of ART since it is an independent predictor of the likelihood of pregnancy.Although the ideal number of oocytes collected after ovum pickup has been a matter of debate in recent years, it seems reasonable to define a typical ovarian response as the retrieval of 10{u2013}15 oocytes after conventional OS.However, a significant proportion of patients who undergo OS are describes according to their response and outcome as poor responders creating an important challenge to the ART

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