Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology

Objectives: The current study was performed to investigate the effect of maternal diabetes on the development and the innervation of circumvallate tongue papillae in their offspring and possible beneficial effect of turmeric administration to the diabetic mother in preventing the defective development. Design: The study was carried on 60 pups from diabetic mother rats that were classified in 2 main groups; group I; untreated diabetic mother rats and group II; diabetic mother rats treated with 30 mg/kg turmeric by oral gavage. The pups were sacrificed at three different ages. The circumvallate papillae were dissected and examined histologically, immunohistochemically for S100 and as well as histomorphometrically.Results: The histopathological results revealed deformed outline of the papillae in the untreated rats{u2019} offspring, decreased number of well-formed taste buds, degenerative effects in Remak{u2019}s ganglion and decreased innervation.Immunohistochemical results showed significant differences between untreated & Turmeric treated groups in terms of S100 expression. Conclusion: Maternal diabetes has a degenerative effect on the taste system of the offspring including the taste buds itself and their intrinsic nervous system and the offspring of diabetic mothers had less number of taste buds and defective innervation than controls and whose mothers were treated with turmeric

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