Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Objective: Measuring of serum taurine as an early marker to detect and prevent complications of diabetic foot. Methods: 90 diabetic patients were selected from the national institute of diabetes and endocrinology (NIDE), 80 patients suffered from diabetic foot and classified into 4 groups according to its surgical complication in their foot and 10 diabetic controlled patients not suffered from diabetic foot considered as diabetic control group. 10 frank healthy non diabetic persons enrolled as volunteers. Complete clinical examination, investigation and biochemical analysis (liver and kidney functions, lipid profile and complete blood count), add to measuring FBG, HbA1c, VEGF and the recent biomarker taurine, was measured for all patient and volunteers. Results: The data showed non significant change in liver functions, kidney functions ,lipid profile, CBC and serum VEGF in all patients regarding to control group (P>0.05). Contrary there is a significance changes in FBG and HbA1c (P<0.05).On the other hand, the data showed very highly significant decrease in serum taurine in all diabetic patients according to the severity of diabetic foot compared to that recorded in healthy control (P<0.001). Conclusion: Serum taurine is reduced in diabetic patients with advanced surgical conditions of diabetic foot. taurine level is considered as an early marker (prognostic) to control complications of diabetic foot

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