Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Introduction: Diabetes is a complex chronic illness, characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. The chronic hyperglycemia associated with diabetes resultedin a subclinical inflammation, which has an important role in the development and progression of type 2 diabetes and its long-term common microvascular complication (Retinopathy, Nephropathy and Neuropathy). Neutrophil to lymphocyte ratio (NLR) is a simple and cheap marker of subclinical inflammation which has been used recently to detect subclinical inflammation in other inflammatory condition and proved to be cost-effective. Aim of work:Evaluate the possibility that neutrophil lymphocyte ratio (NLR) could be used as a predictor of micro-vascular complications in elderly patients with type 2 diabetes. Patients and methods: This study included Sixty elderly type 2 diabetic patients from Kasr Al-Ainy endocrine clinic, the patients aged 65 year or older, diagnosed according to the ADA criteria and grouped into two groups: group 1 is elderly patients with diabetes and hypertension and group 2 is an elderly patients with diabetes.- A full history including drug history and physical examination for every patient were done (neurological and fundus examination included) -Laboratory tests (CBC with differential and Albumin/creatinine ratio) were done and neutrophil/ lymphocyte ratio was calculated.Results: We found that NLR has statistically significant difference in elderly diabetic patients with hypertension in retinopathy and nephropathy with a P. value of 0.004 and 0.044 respectively (P. value<0.05 is statistically significant). However, in group 2 elderly diabetic patients there was no statistical difference in the P. value relating to retinopathy, nephropathy or neuropathy

Issued also as CD