Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: Alopecia Areata (AA) is a common cause of patchy hair loss on the scalp and body. Intralesional corticosteroids (ILCs) is the first-line therapy for patients older than 10 years, however some patients do not respond to glucocorticoid treatment effectively. Also, chemical peels with phenol and lactic acid have been tried successfully in the treatment of alopecia areata. Aim of the work: To evaluate the efficacy of new type of chemical peel (TCA 35%) for the treatment of alopecia areata in comparison to ILCs. Methods: Twenty-two patients with two or more patches of alopecia areata were included in. The mean age of the patients was 25.55 ± 10.62. Two treatment modalities with ILCs and topical TCA 35% were performed in two randomly selected patches. Three sessions were done 3 weeks apart and followed-up for three months. Evaluation was done using Mac Donald Hull and Norris grading system and by counting dermoscopic parameters in each patch. Results: Both ILCs and TCA 35% treated patches showed measurable improvement with no statistically significant difference between the results of the two modalities (p>0.05) at different times of the study. Yellow dots, black dots, exclamation marks and dystrophic hair were all reduced by 100%, 82.0%, 100% and 88.3% in ILCs treated patches and by 70.4%, 69.1%, 100% and 75.0% in TCA treated patches, respectively

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