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Synthesis of some novel pyridine derivatives bearing a sulfonamide moiety of expected anticancer activity with studying the augmenting effect of Þ-radiation / Walid Mohamed Mohamed Soliman Ghorab ; Supervised Fatma Abdelfattah Ragab , Helmy Ismail Heiba

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Walid Mohamed Mohamed Soliman Ghorab , 2019Description: 165 P. : charts ; 25cmOther title:
  • تحضير بعض مشتقات البيريدين الجديدة والتي تحمل مجموعة السلفوناميد والمتوقع لها نشاطا كمضادات للأورام السرطانيه مع دراسة التأثير التحفيزي لأشعة جاما [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2019.Wa.S (Browse shelf(Opens below)) Not for loan 01010110079008000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2019.Wa.S (Browse shelf(Opens below)) 79008.CD Not for loan 01020110079008000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

In a search for new cytotoxic agents with improved activity and selectivity, certain new aminopyridines, pyridones and tyrphostin AG17 analogs bearing a sulfonamide moiety have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human breast carcinoma cell line (MCF-7). Further biological evaluation of the most cytotoxic compounds against cyclin dependent kinase-2 (CDK2) was done. The promising compounds were selected to be evaluated again for their in vitro cytotoxic activity in combination with Þ-radiation. The newly synthesized compounds were docked inside the active site of CDK2 (cyclin-dependent kinase-2) enzyme in an attempt to predict their anticancer mechanism of action

Issued also as CD

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