Effect of erucaria pinnata on chemically induced hepatocellular carcinoma in rats / Marwa Abdelsalam Ibrahim Metwaly ; Supervised Nadia Iskandar Zakhary , Emad Hamza Elgemeie , Adel Kamel Youssef

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Marwa Abdelsalam Ibrahim Metwaly

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Material type: Text

TextLanguage: English Publication details: Cairo : Marwa Abdelsalam Ibrahim Metwaly , 2019Description: 213 P. : charts , facsimiles ; 25cmSubject(s):

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Issued also as CD
Issued also as CD

Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Summary: Some natural products of plant origin are a rich source of cancer chemothutic drugs, and exhibited low toxicity to normal tissues; Family brassicaceae (cruciferae) is one of the most important plant kingdoms, which includes a wide variety of medicinal plants. Erucaria pinnata (Viv.) is a wild annual plant growing in north-western coastal Region. The present study as well to investigate the nutritive value, phytochemical constituents and the cytotoxic activity of methanolic 70% plant extract (E1) and its isolated active compound (rutin) against liver carcinoma cell line (Hep-G2) in vitro and also investigate their chemopreventive efficacy in male rats bearing chemically induced hepatocellular carcinoma (HCC), using diethylnitrosamine (DEN) (200mg/Kg. b.wt., i.p, single dose), after two weeks, animals received carbontetrachloride (CCl4) (3ml/Kg. b.wt., SC, once a week for 6 weeks) and the experiment continued for 44 weeks. The chemical analysis of E. pinnata revealed that, this plant has low nutritive value due to the presence of low concentration of principle phyto-nutrients. The phytochemical screening of the plant extracts showed presence of alkaloids, glycosides, tannins, saponins, phenolices and flavonoids

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.02.Ph.D.2019.Ma.E (Browse shelf(Opens below))		Not for loan		01010110079986000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.02.Ph.D.2019.Ma.E (Browse shelf(Opens below))	79986.CD	Not for loan		01020110079986000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Some natural products of plant origin are a rich source of cancer chemothutic drugs, and exhibited low toxicity to normal tissues; Family brassicaceae (cruciferae) is one of the most important plant kingdoms, which includes a wide variety of medicinal plants. Erucaria pinnata (Viv.) is a wild annual plant growing in north-western coastal Region. The present study as well to investigate the nutritive value, phytochemical constituents and the cytotoxic activity of methanolic 70% plant extract (E1) and its isolated active compound (rutin) against liver carcinoma cell line (Hep-G2) in vitro and also investigate their chemopreventive efficacy in male rats bearing chemically induced hepatocellular carcinoma (HCC), using diethylnitrosamine (DEN) (200mg/Kg. b.wt., i.p, single dose), after two weeks, animals received carbontetrachloride (CCl4) (3ml/Kg. b.wt., SC, once a week for 6 weeks) and the experiment continued for 44 weeks. The chemical analysis of E. pinnata revealed that, this plant has low nutritive value due to the presence of low concentration of principle phyto-nutrients. The phytochemical screening of the plant extracts showed presence of alkaloids, glycosides, tannins, saponins, phenolices and flavonoids

Issued also as CD

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