Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry

Schiff bases and their metal complexes are compounds that can be used for industrial purposes as corrosion inhibitors and catalytic activity and also show a broad range of biological activities including antibacterial, antifungal, antiviral, antimalarial ,anti-inflammatory, anticancer, anti-HIV, and antipyretic properties. In the light of that, two novel Schiff bases namely 1-(6-(1-((4-(4-aminophenoxy)phenyl)imino)ethyl)pyridin-2-yl)ethan-1-one (L1) and 4-(4-((1-(pyridine-2-yl)ethylidene)-amino)phenoxy)aniline (L2) and their complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions were produced and characterized by elemental analyses, mass spectrometry, FT-IR, 1H NMR, molar conductance, and thermal analyses techniques (TG and DTG). The chelates were found to have octahedral geometry. The in vitro antibacterial activity of the ligands and their complexes were also screened. Computational studies of the two Schiff bases ligands had been carried out using DFT/B3LYP method. Molecular docking studies were investigated between the prepared compounds and different protein receptors. The anticorrosion activities of two synthesized Schiff bases (L1 and L2) were evaluated by different electrochemical techniques and confirmed by SEM and EDX

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