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Evaluation of interleukin-10 and transforming growth factor-Ý in human hepatocellular carcinoma cell line subjected to "sorafenib-taurine" therapeutic model / Ahmed Motawa Eisa Elhouseini ; Supervised Ahmed Mohamed Fathi Afifi , Reda Hasan Tabashy , Mohamed Ahmed Khalil

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Motawa Eisa Elhouseini , 2018Description: 101 P. : charts , facsimiles ; 25cmOther title:
  • تقييم " الانترلوكين-10" و" عامل النمو التحويلي - بيتا" في خلايا الكبد السرطاني الخبيث للأنسان بعد التعرض للنموذج العلاجي " سورافينيب - تاورين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Sorafenib (Sor) is a multi-kinase inhibitor, it is recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, Sor has severe and marked side effects. Taurine (Tau) has been shown to enhance the therapeutic effects of cancer chemotherapy and also to enhance the function of leukocytes. Aim of the study: The present study aimed to investigate the immunological aspects of Sor, Taurine as well as after combination on human hepatocytes. Materials and Methods: HepG2 cell line was cultured to determine IC50 using SRB assay. The levels of TGF-Ý and IL-10 released in culture media of the cells were determined by ELISA
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2018.Ah.E (Browse shelf(Opens below)) Not for loan 01010110077430000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2018.Ah.E (Browse shelf(Opens below)) 77430.CD Not for loan 01020110077430000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Sorafenib (Sor) is a multi-kinase inhibitor, it is recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, Sor has severe and marked side effects. Taurine (Tau) has been shown to enhance the therapeutic effects of cancer chemotherapy and also to enhance the function of leukocytes. Aim of the study: The present study aimed to investigate the immunological aspects of Sor, Taurine as well as after combination on human hepatocytes. Materials and Methods: HepG2 cell line was cultured to determine IC50 using SRB assay. The levels of TGF-Ý and IL-10 released in culture media of the cells were determined by ELISA

Issued also as CD

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