New approaches for the synthesis and cytotoxicity of novel heterocyclic compounds and their fused derivatives / Akram George Emmanouel Saad ; Supervised Rafat Milad Mohareb , Sherif Mourad Sherief

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

This work deals with the synthesis and cytotoxicity of some heterocyclic compounds starting from 3-Acetylcoumarin.Several tests as Melting point, IR spectra, 1H-NMR spectra, Mass spectra and Analytical data (element analysis) have been made on all compounds Coumarins are attractive and versatile molecules that find applications in various fields like medicine, perfumery, dyes, pigments, optical brighteners, lasers, optical data storage devices, solar cells. Coumarins (benzopyran-2-ones) constitute an important class of naturally occurring compounds; they are widely used in many fields. Several coumarin derivatives have been synthetically prepared and reported to possess cardiovascular, ageing, antibacterial and photosensitive properties. The chemistry of coumarin has received much attention and is used by chemists to develop several useful products. The chemistry of coumarin has centered on performing reactions at the activated C-3,4-double bond of the Ü,Ý-unsaturated lactone. Based on this chemistry, heterocyclic systems have been built. Coumarins with the desired aromatic substitution were built by synthesis starting from appropriate starting material and/or by electrophilic or nucleophilic substitution

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