Preparation and evaluation of certain gastroretentive drug delivery systems / Mina Mounir Louis ; Supervised Alia Abd Ellatif Badawy , Demiana Ibrahim Nesseem , Nevine Shawky Abdelmalak

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Among the different systems and devices used to control the drug delivery to the GIT, gastroretentive drug delivery systems have attracted much attention of academic researchers.Those systems are advantageous in case of drugs characterized by a narrow absorption window.They provide a prolonged intimate contact with the absorbing membrane; thereby, increasing efficacy. For a successful development of a gastroretentive drug delivery system, the selected dosage form must be able to reside for a time necessary to release the entire drug included before the normal physiology of the stomach can clear up the dosage form to the intestine. Several gastroretentive approaches are being designed and developed, including floating systems, high density systems, mucoadhesive systems, superporous hydrogel systems, expandable systems, and magnetic systems. In this study, we focused specifically on superporous hydrogel systems and effervescent floating mini-tablets formulations.These devices are excellent candidate materials for gastroretentive delivery of many drugs. Drotaverine hydrochloride (DRH) isa non-anticholinergic antispasmodic, which selectively inhibits phosphodiesterase IV.The plasma elimination half-life of DRH is about 7 h.The adult dose is about 40 to 80mg one to three times a day. Furthermore, the drug suffers from brief residence in the highly moving intestine during diarrhea which leads to poor bioavailability and frequent dosing. Therefore, the aim of this thesis is to prepare drotaverine hydrochloride as superporous hydrogel systems and effervescent floating mini-tablets formulae to provide prolonged release, reduce the frequency of dosing and improve patient compliance

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