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Role of fecal neutrophil gelatinase{u2013}associated lipocalin (NGAL) as a biomarker for inflammatory bowel disease / Alshaimaa Mahmoud Mohamed Morsy ; Supervised Hesham Ibrahim Elmakhzangy , Zainab Abdellatif , Normeen Hany Aly Rady

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Alshaimaa Mahmoud Mohamed Morsy , 2020Description: 106 P. : charts , facsimiles ; 25cmOther title:
  • دور الليبوكالين المقترن بجيلاتيناز النيوتروفيل بالبراز كعلامة بيولوجية لمرض الأمعاء الالتهابى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Background Inflammatory bowel disease (IBD) including ulcerative colitis and Crohn{u2019}s disease is increasing in incidence globally and there is no direct method for diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL), is a glycoprotein, which is found to increase during inflammation. Objective Studying the role of fecal NGAL as a biomarker in diagnosing and monitoring IBD patients. Methods The study is an observational cross sectional study including 72 subjects; 26 suffered from UC, 11suffered from CD and 35 healthy controls.Stool samples were collected for measurement of fecal NGAL,Another fecal samples were obtained from twelve UC patients and four CD patients after control of their disease activity by treatments. Results Fecal NGAL demonstrated significantly higher levels in IBD patients compared to the control group. In addition, its level was higher in UC patients compared to CD. The fecal NGAL declined significantly following control of disease activity with treatment; p = 0.0004 Conclusion Fecal NGAL is a useful, reliable, simple and noninvasive biomarkerin diagnosis and monitoring IBD
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2020.Al.R (Browse shelf(Opens below)) Not for loan 01010110081109000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2020.Al.R (Browse shelf(Opens below)) 81109.CD Not for loan 01020110081109000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Background Inflammatory bowel disease (IBD) including ulcerative colitis and Crohn{u2019}s disease is increasing in incidence globally and there is no direct method for diagnosis. Neutrophil gelatinase-associated lipocalin (NGAL), is a glycoprotein, which is found to increase during inflammation. Objective Studying the role of fecal NGAL as a biomarker in diagnosing and monitoring IBD patients. Methods The study is an observational cross sectional study including 72 subjects; 26 suffered from UC, 11suffered from CD and 35 healthy controls.Stool samples were collected for measurement of fecal NGAL,Another fecal samples were obtained from twelve UC patients and four CD patients after control of their disease activity by treatments. Results Fecal NGAL demonstrated significantly higher levels in IBD patients compared to the control group. In addition, its level was higher in UC patients compared to CD. The fecal NGAL declined significantly following control of disease activity with treatment; p = 0.0004 Conclusion Fecal NGAL is a useful, reliable, simple and noninvasive biomarkerin diagnosis and monitoring IBD

Issued also as CD

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