Comparison of attention and memory between smokers and non-smokers using P300 & MMN / Sherien Shehata Zikry Bolis ; Supervised Amira Maged Elshenawy , Noha Ali Hosni , Mona Mohamed Hamdy

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Sherien Shehata Zikry Bolis

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TextLanguage: English Publication details: Cairo : Sherien Shehata Zikry Bolis , 2019Description: 138 P. : charts ; 25cmOther title:

المقارنه بين الانتباه والذاكره بين المدخنين وغير المدخنين باستخدام موجات التوافق السلبيه والموجات الموجبه ب 300 [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of E.N.T Summary: Background: Several studies show that nicotine has pharmacological properties related to the deterioration of cognitive processing, namely attention while improving the auditory memory processing. This performance can be evaluated though electrophysiological tests such as the P300, which is highly dependent on cognitive skills, including attention and discrimination, and the Mismatch Negativity (MMN), dependent on auditory memory. Objective: The goal of the present study is to identify the effect of cigarette smoking on cognitive function of the brain, as reflected by P300 and its effect on auditory automatic processing, as reflected by MMN in smoker and non-smoker subjects. Methods: The electrophysiological P300 and MMN tests were performed in a group of 40 smoking individuals and a group of 40 non-smokers, both aged between 20 and 50 years old. To obtain the P300 and MMN, the same protocol was used on all subjects. Both tests were evoked by an oddball paradigm and stimulation was monaural. For P300, each individual had to mentally count the rare stimulus while in MMN; the individuals had to watch a movie in silence. Results: Comparison between smokers and non-smokers revealed statistically significant differences regarding P300 amplitude, showing decrease P300 amplitude in smoking group indicating delayed information processing. Thus, chronic tobacco smoking may produce prefrontal cognitive dysfunction. In addition, there is statistically a difference regarding MMN, showing increase MMN amplitude and latency in smoking subjects, this may suggest further information decoding, promoting the formation of auditory memory. There was a positive correlation between P300, MMN amplitudes and smoking level indicating that, , there was some evidence for a dose- response relationship between cigarette smoking and P300 amplitude reduction in P300 and increased MMN amplitude in MMN

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.12.M.Sc.2019.Sh.C (Browse shelf(Opens below))		Not for loan		01010110079668000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.12.M.Sc.2019.Sh.C (Browse shelf(Opens below))	79668.CD	Not for loan		01020110079668000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of E.N.T

Background: Several studies show that nicotine has pharmacological properties related to the deterioration of cognitive processing, namely attention while improving the auditory memory processing. This performance can be evaluated though electrophysiological tests such as the P300, which is highly dependent on cognitive skills, including attention and discrimination, and the Mismatch Negativity (MMN), dependent on auditory memory. Objective: The goal of the present study is to identify the effect of cigarette smoking on cognitive function of the brain, as reflected by P300 and its effect on auditory automatic processing, as reflected by MMN in smoker and non-smoker subjects. Methods: The electrophysiological P300 and MMN tests were performed in a group of 40 smoking individuals and a group of 40 non-smokers, both aged between 20 and 50 years old. To obtain the P300 and MMN, the same protocol was used on all subjects. Both tests were evoked by an oddball paradigm and stimulation was monaural. For P300, each individual had to mentally count the rare stimulus while in MMN; the individuals had to watch a movie in silence. Results: Comparison between smokers and non-smokers revealed statistically significant differences regarding P300 amplitude, showing decrease P300 amplitude in smoking group indicating delayed information processing. Thus, chronic tobacco smoking may produce prefrontal cognitive dysfunction. In addition, there is statistically a difference regarding MMN, showing increase MMN amplitude and latency in smoking subjects, this may suggest further information decoding, promoting the formation of auditory memory. There was a positive correlation between P300, MMN amplitudes and smoking level indicating that, , there was some evidence for a dose- response relationship between cigarette smoking and P300 amplitude reduction in P300 and increased MMN amplitude in MMN

Issued also as CD

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