Frequency of hypodontia after chemotherapy in childhood cancer survivors : A cross sectional study / Ghada Adel Mahmoud Tahoun ; Supervised Amr Ezzat Abdullatif , Lobna Mohamed Elamin Shalaby , Sara Ahmed Mahmoud

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Pedodontics

Aim: This cross sectional study was designed to provide information on the frequency of hypodontia in children cancer survivors who received chemotherapy before 4 years of age. Methods: The study sample included 144 cancer survivors who received anti neoplastic chemotherapy at the Children Cancer Hospital Egypt 57357. Subjects were selected using stratified random sampling and those who met the eligibility criteria were asked to attend to fill a questionnaire followed by taking a panoramic radiograph. Dental Panoramic radiographs were examined to assess dental abnormalities, excluding third molars, which were then evaluated using Holtta{u2019}s Defect Index (DeI). Results: The Mean age of the study sample was 10.22 (± 2.81) years old at examination and 2.56 (± 1.02) years at start of chemotherapy. The mean DeI for the study population was 9.3± 10.13. 70.14% of the study population had at least one dental anomaly. The total frequency of hypodontia in the study population was 9.72%. In the current study, hypodontia occurred mostly in second premolars (54.17%) followed by second permanent molars (20.83%), first premolars (16.66%) and lateral incisors (8.34%). Also, it occurred most commonly with bone tumors 1 out of 3 (33.33 %), followed by Langerhan{u2019}s Cell Histiocytosis 2 out of 7 (28.57 %) where as the least counts revealed were with Acute Lymphoblastic Leukemia 2 out of 55 (3.64 %) and no results were found with Acute Myeloid Leukemia, Brain tumors, Germ Cell Tumor, Hodgkin{u2019}s Lymphoma, and Soft tissue sarcomas

Issued also as CD