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Antiseptic effect of Sepia officinalis against hepatorenal injury in rats / Asmaa Abdelaleem Abdellatif Mohamed ; Supervised Sohair Ramadan Fahmy , Amel Mahmoud Ali Soliman , Amany Ahmed Sayed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Asmaa Abdelaleem Abdel Latif Mohamed , 2016Description: 239 P. : charts , facimiles ; 25cmOther title:
  • تأث{u٠٦أأ}ر الحبار المضاد لتعفن الدم ضد الإصابة الكبدية الكلوية في الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Sepsis remains a major problem for both scientists and clinicians. Cecal ligation and puncture (CLP) considered as the gold standard for animal models of sepsis. The aim of the present study was to assess the complications which associated with sepsis induced by CLP and the potential curative role of Sepia officinalis body tissue (SOBT) and Sepia officinalis polysaccharide (SOP) extracts in hepatorenal injury induced by CLP. Fourty eight male albino rats (12 rats/each group) were divided into four groups, the Sham-operated control, CLP, SOBT and SOP groups. Both Sham and CLP groups administered distilled water while, SOBT and SOP treated groups administered SOBT and SOP for 2 days after CLP. On the third day, half of the rats were euthanized for samples collection. But, the other half was still live and used for survival study. The present study revealed that the SOBT and SOP extracts showed in vitro bactericidal activity against Gram positive and Gram negative bacteria. Furthermore, SOBT extract and SOP treatment increase the percentage of survival rate of the rats by (66.7%) and (83.33%), respectively, as compared to the untreated CLP rats. In addition, the results revealed that CLP operation caused anemia, leukocytosis, thrombocytopenia, elevation in procalcitonin level and oxidative stress in liver and kidney of rats, which have bad impacts on liver and kidney functions and decrease in cytochrome P450 1A2 activity. However, SOBT and SOP showed their ability to improve the hematological parameters, procalcitonin level and reduce the oxidative stress; which caused significant improvement in most of the biochemical parameters. Also, histopathological examination showed an improvement in the liver and the kidney architecture of the treated groups comparable with untreated one
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2016.As.A (Browse shelf(Opens below)) Not for loan 01010110069657000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2016.As.A (Browse shelf(Opens below)) 69657.CD Not for loan 01020110069657000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Sepsis remains a major problem for both scientists and clinicians. Cecal ligation and puncture (CLP) considered as the gold standard for animal models of sepsis. The aim of the present study was to assess the complications which associated with sepsis induced by CLP and the potential curative role of Sepia officinalis body tissue (SOBT) and Sepia officinalis polysaccharide (SOP) extracts in hepatorenal injury induced by CLP. Fourty eight male albino rats (12 rats/each group) were divided into four groups, the Sham-operated control, CLP, SOBT and SOP groups. Both Sham and CLP groups administered distilled water while, SOBT and SOP treated groups administered SOBT and SOP for 2 days after CLP. On the third day, half of the rats were euthanized for samples collection. But, the other half was still live and used for survival study. The present study revealed that the SOBT and SOP extracts showed in vitro bactericidal activity against Gram positive and Gram negative bacteria. Furthermore, SOBT extract and SOP treatment increase the percentage of survival rate of the rats by (66.7%) and (83.33%), respectively, as compared to the untreated CLP rats. In addition, the results revealed that CLP operation caused anemia, leukocytosis, thrombocytopenia, elevation in procalcitonin level and oxidative stress in liver and kidney of rats, which have bad impacts on liver and kidney functions and decrease in cytochrome P450 1A2 activity. However, SOBT and SOP showed their ability to improve the hematological parameters, procalcitonin level and reduce the oxidative stress; which caused significant improvement in most of the biochemical parameters. Also, histopathological examination showed an improvement in the liver and the kidney architecture of the treated groups comparable with untreated one

Issued also as CD

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