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A genotyping and posttranscriptional regulatory mechanism study of the cytotoxic T - lymphocyte antigen - 4 (CTLA4) gene associated with type 1 diabetes disease in Egypt / Hatem Mohamed Saleh ; Supervised Bahia Riad Abdou , Mohamed Sayed Salama

By: Contributor(s): Material type: TextTextLanguage: eng Publication details: Cairo : Hatem Mohamed Saleh , 2010Description: 238Leaves : charts ; 30cmOther title:
  • دراسةالطفرات الوراثية وميكانيزم مابعد النسخ للحمض الريبوزى النووى لجين (سى تى أل أيه 4) المصاحب لمرض السكر النوع الأول فى مصر [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: Type 1 diabetes (TID) is an organ - specific autoimmune disease characterized by T cell - mediated destruction of pancreatic islets . T cell proliferation is negatively regulated by cytotoxic lymphocyte antigen - 4 (CTLA - 4) CTLA - 4 polymorphisms are associated with TID in some but not all populations . We investigated the prevalence of the selected single nucleotide polymorphisms (SNPs) in the entire CTLA - 4 gene sequence and di - nucleotide repeats polymorphism (AT)n of 3' UTRregion in the CTLA4 gene with the 396 egyptian patients {u2264} 14 years old and 396 control subjects> 24 years old with a similar ratio of males to females in both groups
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2010.Ha.G (Browse shelf(Opens below)) Not for loan 01010110053247000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2010.Ha.G (Browse shelf(Opens below)) 53247.CD Not for loan 01020110053247000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

Type 1 diabetes (TID) is an organ - specific autoimmune disease characterized by T cell - mediated destruction of pancreatic islets . T cell proliferation is negatively regulated by cytotoxic lymphocyte antigen - 4 (CTLA - 4) CTLA - 4 polymorphisms are associated with TID in some but not all populations . We investigated the prevalence of the selected single nucleotide polymorphisms (SNPs) in the entire CTLA - 4 gene sequence and di - nucleotide repeats polymorphism (AT)n of 3' UTRregion in the CTLA4 gene with the 396 egyptian patients {u2264} 14 years old and 396 control subjects> 24 years old with a similar ratio of males to females in both groups

Issued also as CD

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