Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Background:The growing prevalence of obesity is a cause of concern worldwide, as the World Health Organization (WHO) declared more than 10% of the world{u2019}s adult population overweight obese as of 2008. Every year about 3.4 million adults die because of overweight or obesity.In the course of obesity, triglycerides (TG) are accumulated as ectopic fat in non-adipose tissues to meet the demand of storing excessive energy following the phases of hypertrophy and hyperplasia of adipocytes .Two organs that are heavily affected by visceral fat deposition in obese subjects are the liver and the pancreas. Liver is the primary organ for ectopic fat accumulation, causing the well{u2010}characterized nonalcoholic fatty liver disease (NAFLD), which is becoming the most common cause of chronic liver disease in children and adults. Non-alcoholic fatty pancreas disease is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption. It is becoming an increasingly recognized condition, with an estimated prevalence of 16-35% in adults and also present in 67% of patients with NAFLD. Moreover, it{u2019}s been associated with several of NAFLD risk factors such as obesity, MetS, hyperlipidemia, visceral fat and insulin resistance/T2DM.Aim: The aim of this study was to investigate the prevalence of NAFPD in NAFLD patients and to explore the factors associated with risk of NAFPD. Fifty eight patientswere recruited fromKasr Al-Ainyoutpatients{u2019} clinics from September 2019 to February 2020. Results:The present study demonstrated the strong correlation between NAFLD and NAFPD in a selected group of NAFLD as part of the metabolic syndrome patients presenting to the outpatient clinics of Kasr Al-Ainy university hospitals. Ninety-three per cent (93%) of the study participants showed evidence of pancreatic steatosis on transabdominal ultrasonography and higher ultrasonographic grade of hepatic steatosis was significantly correlated to the grade of pancreatic steatosis

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