Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Background: Early outcome prediction in ischemic stroke is a crucial concern for clinicians for proper decisions to reduce morbidity and mortality. The present study aimed to compare between CT perfusion, NIHSS, and S100Ý for early outcome prediction. Methods: The study was carried out on 50 adult patients with acute ischemic stroke, classified into two groups according to mRS score into Group I (Favorable outcome) and group II (unfavorable outcome). CTP was done on admission, NIHSS was calculated on admission, and Blood was withdrawn on admission and third day for S100Ý, Results: Infarction core size and the penumbra size were larger significantly in unfavorable outcome group (p<0.001). Also, as regard S100Ý levels and NIHSS on admission were higher in group 2 than group 1 significantly (p< 0.001, 0.001; respectively). AUCs were 0.787 for NIHSS score, 0.877 for S100Ý level, and 0.844 for penumbra size. Combination between penumbra size, S100Ý, and NIHSS to predict outcome. The ROC curve yielded and AUC of 0.905 p<0.001. Furthermore, the comparison between combination of penumbra size, S100Ý, NIHSS on admission, and the final infarct are in noncontrast CT (NCCT) on day 3 had significant positive correlation coefficient (r= 0.577, p<0.001)

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