Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: psoriasis vulgaris is a chronic inflammatory disease characterized by remissions and exacerbations.The pathogenesis is complex and involves genetic, environmental and immunological factors.Psoriasis is commonly associated with a number of comorbid conditions including cardiometabolic, stroke, metabolic syndrome and malignancy. Metabolic syndrome encompasses multiple interrelated metabolic parameters including abdominal obesity, insulin resistance, dysglycemia,dyslipidemia and hypertension.The pathogenesis of metabolic syndrome is still unclear.Psoriasis and metabolic syndrome may co-exist due to a shared immuopathogenesis involving chronic low level inflammation mediated by pro-inflammatory cytokines.IL-36 cytokines (subtype of IL-1 family) are considered pathogenic drivers of psoriasis whereas IL-38 cytokines are downregulated in psoriatic lesions. However, little is known about their role in metabolic syndrome development. Aim of work: The current study aimed at evaluation of the levels of serum IL-36 and IL-38 in psoriasis vulgaris and their relation to the metabolic syndrome. Patients and methods: This study included twenty psoriasis patients with metabolic syndrome, twenty psoriasis patients without metabolic syndrome, twenty metabolic controls and twenty healthy controls. Each patient was subjected to short medical history and clinical examination. Serum samples III were drawn from each participant and IL-36 and IL-38 levels were measured using Human Interleukin 36 ELISA kit and Human Interleukin 38 ELISA kit respectively

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