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Significance of CkMb to total cpk ratio in critically ill children / Dina Mahmoud Mohamed Ahmed ; Supervised Johne Rene Labib , Mohamed Samir Eid , Eman Alhussain Abdulgawad

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Dina Mahmoud Mohamed Ahmed , 2021Description: 95 P . : charts , facsimiles ; 25cmOther title:
  • اهميه حساسيه معدل الكرياتين كيناز الخاص بعضله القلب الى إجمالى نسبه الكرياتين فسفو كيناز بالجسم فى الأطفال مرضى الحالات الحرجه [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Introduction: Acute severe myocardial dysfunction remains a significant cause of mortality and morbidity in children requiring intensive care. In ICU patients, physiologic stresses can occur in the form of either increased myocardial oxygen demands or decreased myocardial oxygen delivery resulting in cardiac dysfunction, cardiac injury, or both. CKMB is one of the three creatinine-kinase isoenzymes expressed in the heart (=22% of the total CK content) and skeletal muscle (=1-3%). It is usually undetectable or in low levels in the blood except in the presence of both heart and skeletal diseases. Still no more studies have been evaluated the value of CKMB to total CPK in critically ill children to determine its effect in evaluation of myocardial injury. Aim of the study: To evaluate the sensitivity of Creatinine Kinase Myocardial Band to total Creatinine Phospho- Kinase in critically ill children and its evaluation as a marker for myocardial dysfunction in these patients. Patient and methods: our study was a comparative cross-sectional study which was performed on 102 critically ill children who were admitted to PICU of children's hospital, Cairo University to evaluate the sensitivity of CKMB to total CK ratio in myocardial dysfunction in critically ill children. All the included children were subjected to full history taking, clinical examination, and investigations including CKMB to total CK ratio.Results: The present study revealed statistically significant difference between 2 groups (CKMB/CPK<0.51) and (CKMB/CPK >0.51) as regards cardiopulmonary causes (being mostly >0.51), neurometabolic causes (being mostly<.51), renal ((being mostly <0.51), and sepsis ((being mostly <0.51), with p-value <0.05. The present study revealed statistically significant difference between 2 groups (CKMB/CPK<0.42) and (CKMB/CPK >0.42) as regards outcome (died or survived) with p-value <0.001
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2021.Di.S (Browse shelf(Opens below)) Not for loan 01010110083697000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2021.Di.S (Browse shelf(Opens below)) 83697.CD Not for loan 01020110083697000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: Acute severe myocardial dysfunction remains a significant cause of mortality and morbidity in children requiring intensive care. In ICU patients, physiologic stresses can occur in the form of either increased myocardial oxygen demands or decreased myocardial oxygen delivery resulting in cardiac dysfunction, cardiac injury, or both. CKMB is one of the three creatinine-kinase isoenzymes expressed in the heart (=22% of the total CK content) and skeletal muscle (=1-3%). It is usually undetectable or in low levels in the blood except in the presence of both heart and skeletal diseases. Still no more studies have been evaluated the value of CKMB to total CPK in critically ill children to determine its effect in evaluation of myocardial injury. Aim of the study: To evaluate the sensitivity of Creatinine Kinase Myocardial Band to total Creatinine Phospho- Kinase in critically ill children and its evaluation as a marker for myocardial dysfunction in these patients. Patient and methods: our study was a comparative cross-sectional study which was performed on 102 critically ill children who were admitted to PICU of children's hospital, Cairo University to evaluate the sensitivity of CKMB to total CK ratio in myocardial dysfunction in critically ill children. All the included children were subjected to full history taking, clinical examination, and investigations including CKMB to total CK ratio.Results: The present study revealed statistically significant difference between 2 groups (CKMB/CPK<0.51) and (CKMB/CPK >0.51) as regards cardiopulmonary causes (being mostly >0.51), neurometabolic causes (being mostly<.51), renal ((being mostly <0.51), and sepsis ((being mostly <0.51), with p-value <0.05. The present study revealed statistically significant difference between 2 groups (CKMB/CPK<0.42) and (CKMB/CPK >0.42) as regards outcome (died or survived) with p-value <0.001

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