Evaluation of growth hormone efficacy in the different indication of growth hormone deficiency / Eatemad Helmy Moubarak ; Supervised Abeer Atef Elashmawy , Sahar Yassin Ibrahim , Nora Elsaid Badawy

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Background: Short stature is one of the commonest chronic problems encountered in pediatric practice. Objectives: To study the characteristic anthropometric and demographic criteria for the GH therapy (GHT) in Egyptian health insurance regarding etiology and response to GH therapy and to determine the cost benefit value of GHT in the different GH indications. Subject and methods: In this retrospective study 500 short children treated with recombinant GH were examined for growth assessments and response to GHT. Patients were classified into turner syndrome (TS), growth hormone deficiency (GHD), Idiopathic short stature (ISS), silver russell syndrome, multiple pituitary hormonal deficiency (MPHD) and small for gestational age (SGA). Results: Patients with complete GHD had a better growth response (GV/year) (0.76±2.74 SDS) than patients with partial GHD (0.14±1.67 SDS), Patients with GHD had height gain (6.15±1.63 cm) higher than patients with ISS (5.92±1.34 cm), There was significant difference regarding the cost of GH therapy / year (P- value =0.01), as it was higher in patients with ISS than patients with GHD, Girls of Turner syndrome have a better chance for height gain and it is better to be referred to their growth standards and The most significant factors affecting the gain height were age at diagnosis, height at presentation SDS, dose of GH mg/kg/d, duration of therapy and peak of GH by clonidine

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