Role of cold laser as an alternative tool to bariatric surgeries in modifying sirtuin1 gene expression in obese down syndrome patients / Mohamed Maher Ahmed Elkeblawy ; Supervised Zakaria Mowafy Emam Mowafy , Ehab Ragae , Khowailed Abdelhaleem Khowailed

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Mohamed Maher Ahmed Elkeblawy

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TextLanguage: English Publication details: Cairo : Mohamed Maher Ahmed Elkeblawy , 2017Description: 126 P. : charts , facsimiles ; 25cmOther title:

دور الليزر البارد كوسيلة بديلة لجراحات السمنة المفرطة على تعديل التعبير الجينى لجين السرتوين1 فى مرضى متلازمة داون البدناء [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Surgery Summary: Background : Down syndrome has a higher risk for developing obesity. The significant association between abdominal visceral fat accumulation and sirtuin: SIRT1 may be a new therapeutic target for the prevention of diseases related to obesity Purpose: the current study was conducted to investigate the effect of cold laser as alternative tool to bariatric surgery on modifying SIRT1 gene expression in obese down syndrome patients. Methods : Forty obese down syndrome patients were included in curent study. Their IQ level was grater than 60. Their ages were ranged from 14 to 18 years, their body mas index (BMI) were ranged from 30kg/m2 to 39,9 kg/m2, These patients were divided randomly and equally into two groups G1 was included twenty obese patients with down syndrome. They were exposed to cold loser on abdominal adipose tissue two times/ week for 3 months plus indoor ergonomic exercise two times / week for 3 months plus balanced diet. G2 composed of twenty obese patient with down syndrome. They were received indoor ergonomic exercise two times/ weeks for three months plus balanced diet , measurements were performed before study ( pre-test) and after three months (post-test). Assessment included BMI, abdominal circumference, skinfold and SIRT1 level. Results: statistical analysis revealed that there was reduction of BMI, waist circumference and skin fold as well as fold change within both groups after treatment in compare to pre treatment (p>0.05). Also there was a significant reduction in skin fold in group I compared with group II )P>0.05). In spite of there was no significant difference in the BMI, waist circumference, and fold change between both groups )P<0.05) before treatment. As regards , in post treatment there was a clinical difference of BMI in favor to G2 (11.69%) compared to G1 (6.93) and waist circumference in G1 (18.29) compared with G2 (11%), As regards the fold change was favor in G2 ( 40%) while it was 27.27% in G1

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.21.07.Ph.D.2017.Mo.R (Browse shelf(Opens below))		Not for loan		01010110073267000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.21.07.Ph.D.2017.Mo.R (Browse shelf(Opens below))	73267.CD	Not for loan		01020110073267000

Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Surgery

Background : Down syndrome has a higher risk for developing obesity. The significant association between abdominal visceral fat accumulation and sirtuin: SIRT1 may be a new therapeutic target for the prevention of diseases related to obesity Purpose: the current study was conducted to investigate the effect of cold laser as alternative tool to bariatric surgery on modifying SIRT1 gene expression in obese down syndrome patients. Methods : Forty obese down syndrome patients were included in curent study. Their IQ level was grater than 60. Their ages were ranged from 14 to 18 years, their body mas index (BMI) were ranged from 30kg/m2 to 39,9 kg/m2, These patients were divided randomly and equally into two groups G1 was included twenty obese patients with down syndrome. They were exposed to cold loser on abdominal adipose tissue two times/ week for 3 months plus indoor ergonomic exercise two times / week for 3 months plus balanced diet. G2 composed of twenty obese patient with down syndrome. They were received indoor ergonomic exercise two times/ weeks for three months plus balanced diet , measurements were performed before study ( pre-test) and after three months (post-test). Assessment included BMI, abdominal circumference, skinfold and SIRT1 level. Results: statistical analysis revealed that there was reduction of BMI, waist circumference and skin fold as well as fold change within both groups after treatment in compare to pre treatment (p>0.05). Also there was a significant reduction in skin fold in group I compared with group II )P>0.05). In spite of there was no significant difference in the BMI, waist circumference, and fold change between both groups )P<0.05) before treatment. As regards , in post treatment there was a clinical difference of BMI in favor to G2 (11.69%) compared to G1 (6.93) and waist circumference in G1 (18.29) compared with G2 (11%), As regards the fold change was favor in G2 ( 40%) while it was 27.27% in G1

Issued also as CD

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