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Pharmacognostical investigation of some yucca species (asparagaceae) / Samar Mohamed Bassam Moaz ; Supervised Seham Salah Eldin Elhawary , Abeer Mohamed Ali Elsayed , Elmoataz Bellah Ali Elnaggar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samar Mohamed Bassam Moaz , 2019Description: 272 P. : charts , facsimiles ; 25cmOther title:
  • دراسة عقاقيرية لبعض أنواع اليوكا - العائلة الأسبارجية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy Summary: Yucca is a genus of woody perennial shrubs and trees, native to Central America northward to southernmost Canada. This genus is highly reputed for its economic importance as a source of fibers and saponins for rope and soap industries, respectively. Yucca aloifolia L., and its variety Yucca aloifolia variegata L., Yucca filamentosa L. and Yucca elephantipes Regel leaves were collected from Orman Botanical Garden, to investigate their biological activities and to carry on phytochemical investigation of the most active species. The plants were first subjected to thorough botanical study and DNA fingerprinting to aid their authentication and identification in any future study. Biological investigation of the total alcoholic extracts of the leaves of the 4 plants, lead to the conclusion of the excellent hepatoprotective effect of the 4 plants using in-vivo CCl4-induced hepatotoxicity model. In-vitro cytotoxicity investigation proved the outstanding cytotoxic activity of Y. aloifolia variegata L.,especially against hepatocellular carcinoma and breast cancer cell lines. However, antimicrobial activity screening showed the lack of activity in both water and alcoholic extracts of the 4 plants.As a result, Y. aloifolia variegata L. was considered the most active and was subjected to further phytochemical investigation. This included preliminary phytochemical screening, determination of total phenolic content, quantitative and qualitative determination of flavonoids and phenolic acids in fraction using HPLC, investigation of lipoid content using GC-MS for both saponifibale and unsaponifiable fractions, and finally LC-MS/MS of the total extract and some fractions. LC-MS/MS was used to for identification of 10 isolated compounds
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2019.Sa.P (Browse shelf(Opens below)) Not for loan 01010110079459000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.07.Ph.D.2019.Sa.P (Browse shelf(Opens below)) 79459.CD Not for loan 01020110079459000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

Yucca is a genus of woody perennial shrubs and trees, native to Central America northward to southernmost Canada. This genus is highly reputed for its economic importance as a source of fibers and saponins for rope and soap industries, respectively. Yucca aloifolia L., and its variety Yucca aloifolia variegata L., Yucca filamentosa L. and Yucca elephantipes Regel leaves were collected from Orman Botanical Garden, to investigate their biological activities and to carry on phytochemical investigation of the most active species. The plants were first subjected to thorough botanical study and DNA fingerprinting to aid their authentication and identification in any future study. Biological investigation of the total alcoholic extracts of the leaves of the 4 plants, lead to the conclusion of the excellent hepatoprotective effect of the 4 plants using in-vivo CCl4-induced hepatotoxicity model. In-vitro cytotoxicity investigation proved the outstanding cytotoxic activity of Y. aloifolia variegata L.,especially against hepatocellular carcinoma and breast cancer cell lines. However, antimicrobial activity screening showed the lack of activity in both water and alcoholic extracts of the 4 plants.As a result, Y. aloifolia variegata L. was considered the most active and was subjected to further phytochemical investigation. This included preliminary phytochemical screening, determination of total phenolic content, quantitative and qualitative determination of flavonoids and phenolic acids in fraction using HPLC, investigation of lipoid content using GC-MS for both saponifibale and unsaponifiable fractions, and finally LC-MS/MS of the total extract and some fractions. LC-MS/MS was used to for identification of 10 isolated compounds

Issued also as CD

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