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Analytical determination of some pharmaceutical compounds using different / Eman Gamal sayed Ahmed ; Supervised Mahmoud Sabry Rizk , Fatehy Mohamed Abdelhaleem

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Gamal sayed Ahmed , 2021Description: 64 P. : charts , facsimiles ; 25cmOther title:
  • التقدير التحليلى لبعض المركبات الصيدلانية باستخدام مجسات مختلفة [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry Summary: Two developed electrochemical biosensors were constructed for potentiometric determination of Ivabradine hydrochloride (IVB) in physiological fluids. The carbon-paste electrodes (CPEs) were constructed using nitrophenyl octyl ether as a plasticizer, graphite as source of carbon, Fe₂O₃ nanoparticles decorated multiwalled carbon nanotubes (Fe₂O₃@MWCNTs) as a modifier, t-butyl calixarene (t-BCX) or tailored molecularlyimprinted polymer (MIP) as ionophores. Loading the Fe2O3@MWCNTs into the CPEs increases the sensitivity and detection limit of the biosensors comparing with loading unmodified MWCNTs. MIP- and t-BCX-based CPEs exhibit Nernstian response of 56.0 and 58.9 mV decade-1 over drug concentration ranges of 10-3-10-8 and 10-3-10-7 M with detection limits of 9.8{u00D7}10-8 and 3.6{u00D7}10-8 M, respectively. Cavities in MIP and t-BCX are suitable for IVB masking with different complexing strengths, which were estimated by the sandwich membrane method (SMM). The developed biosensors exhibit better selectivity and higher formation constant because the cavities are tailored and more fitted for IVB. The developed biosensors are Sensitive for IVB determination in urine, serum and pharmaceutical preparations (Savapran®)
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2021.Em.A (Browse shelf(Opens below)) Not for loan 01010110084969000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.08.M.Sc.2021.Em.A (Browse shelf(Opens below)) 84969.CD Not for loan 01020110084969000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry

Two developed electrochemical biosensors were constructed for potentiometric determination of Ivabradine hydrochloride (IVB) in physiological fluids. The carbon-paste electrodes (CPEs) were constructed using nitrophenyl octyl ether as a plasticizer, graphite as source of carbon, Fe₂O₃ nanoparticles decorated multiwalled carbon nanotubes (Fe₂O₃@MWCNTs) as a modifier, t-butyl calixarene (t-BCX) or tailored molecularlyimprinted polymer (MIP) as ionophores. Loading the Fe2O3@MWCNTs into the CPEs increases the sensitivity and detection limit of the biosensors comparing with loading unmodified MWCNTs. MIP- and t-BCX-based CPEs exhibit Nernstian response of 56.0 and 58.9 mV decade-1 over drug concentration ranges of 10-3-10-8 and 10-3-10-7 M with detection limits of 9.8{u00D7}10-8 and 3.6{u00D7}10-8 M, respectively. Cavities in MIP and t-BCX are suitable for IVB masking with different complexing strengths, which were estimated by the sandwich membrane method (SMM). The developed biosensors exhibit better selectivity and higher formation constant because the cavities are tailored and more fitted for IVB. The developed biosensors are Sensitive for IVB determination in urine, serum and pharmaceutical preparations (Savapran®)

Issued also as CD

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