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Interleukin-23r gene polymorphism in pediatric Egyptian patients with primary immune thrombocytopenia / Eman Othman Ebrahim Ali ; Supervised Hala Mohammad Farawela , Shahira Kamal Anis , Mona Kamal Elghamrawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Eman Othman Ebrahim Ali , 2015Description: 136 P. : facsimiles ; 25cmOther title:
  • تعدد اشكال جين مستقبل الانترلوكين ٢٣ للاطفال المصريين المصابين بمرض الفرفورة الدموية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology Summary: Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of anti-platelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Aim:The current case-control study aimed at detecting the frequency of IL-23R gene polymorphism in egyptian children with ITP and its possible role as a genetic marker for ITP risk. Materials and Methods: IL-23R gene polymorphism was studied in 50 ITP patients and 100 healthy age and sex matched controls by PCR amplification of the target gene followed by allele specific restriction enzyme digestion (RFLP technique). Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Em.I (Browse shelf(Opens below)) Not for loan 01010110066916000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2015.Em.I (Browse shelf(Opens below)) 66916.CD Not for loan 01020110066916000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology

Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of anti-platelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Aim:The current case-control study aimed at detecting the frequency of IL-23R gene polymorphism in egyptian children with ITP and its possible role as a genetic marker for ITP risk. Materials and Methods: IL-23R gene polymorphism was studied in 50 ITP patients and 100 healthy age and sex matched controls by PCR amplification of the target gene followed by allele specific restriction enzyme digestion (RFLP technique). Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.

Issued also as CD

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