Epidemiological profile of fatty liver and predictors for grading differentiation : Hospital-based study / Mohammed Mustafa Abdelrazik ; Supervised Mona Soliman Mohammed Ahmed , Eman Taher Alsayed , Ola Abdelmoniem Mostafa

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Community Medicine

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide, affecting 5%-40% of the general population. Prevalence of NAFLD, including Nonalcoholic steatohepatitis (NASH), is rising in parallel with the increasing prevalence of obesity, type 2 DM, and metabolic syndrome. A certain proportion of NASH patients progress to cirrhosis and hepatocellular carcinoma (HCC). Aim of work: is to determine the epidemiological features and potentially preventable risk factors for fatty liver disease. Subjects and Methods: This study involved 150 consented patients attending the outpatient clinic of tropical medicine at Cairo university Hospital for ultra-sonographic assessment. A pre-coded structured questionnaire was used to obtain data regarding participants' personal and family history, socio-economic status, fat screener, and food frequency. In addition, anthropometric measurements, clinical as well as laboratory investigations were assessed. Results: On the univariate level; Participants with severe fatty liver were significantly associated with old age, heavy weight, high BMI, presence of diabetes mellitus, high levels of total cholesterol, triglycerides and LDL. On the multivariate level; only BMI, total cholesterol and LDL were the significant independent risk factors of severe hepatic steatosis (R2=0.543). Logit (P of severe fatty liver) = -25.717+0.440 (BMI) +0.031 (T. cholesterol) +0.023 (LDL). Conclusion: High BMI, total cholesterol and LDL were considered predictors of severe hepatic steatosis

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