Good quality verification of certain antimicrobial / Fatma Mahmoud Aboul Alamain ; Supervised Ezzat M. Abdelmoety , Amr M. Badawey , Hebatallah M. Essam

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This thesis demonstrates three parts which are; general introduction and two other parts describe literatures and different techniques for the quantitative analysis of the cited drugs in presence of their degradation products in raw materials and in their pharmaceutical preparation and appendix in addition to references and summary in Arabic. General introduction: This part presents a general introduction about antimicrobial drugs, explains the concept of quality verification in analysis and analytical method validation procedures and demonstrates the aims of the present work. Selective determination of the antimicrobial gemifloxacin. Section ii A: introduction and literature review an introduction describes the chemical structure, physical properties, and pharmacological action of gemifloxacin (GEM) and a brief review of the published analytical procedures developed for its analysis. Section II B: gemifloxacin stability study: This section investigates the stability of GEM under acid and alkaline degradation conditions as well as characterization of the degradation products. Suggestion of the pathway of the degradation process was presented

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