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Prevalence and genetic background of clarithromycin resistance of helicobacter pylori strains in Egyptian patients / Gehan Mostafa Saeed Ahmed ; Supervised Iman Ismail Ramzy , Mohammad Ahmed Mohey Eldin , Doaa Mohammad Abdelatty

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Gehan Mostafa Saeed Ahmed , 2015Description: 97 P. : facsimiles ; 25cmOther title:
  • مدى انتشار مقاومة عقار الكلاريثروميسين لفصائل البكتيريا الحلزونية فى المرضى المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine Summary: Clarithromycin-based eradication therapy regimens represent the gold standard in management of H. pylori organism. Clarithromycin resistance is the main cause of failure of eradication therapy which may be due to multiple genetic mutations, single or combined together. Aim of work: Determining the prevalence and the genetic background of clarithromycin resistance of the H. Pylori strains isolated from gastric biopsies in Egyptian patients. Patients and methods : Gastric biopsies were obtained from 100 egyptian patients having upper gastrointestinal manifestations. Biopsies underwent PCR for detecting H pylori organism then PCR-RFLP to detect clarithromycin resistance. Results : H pylori was detected in 70 patients, of them, 35 cases were resistant to clarithromycin CONCLUSION : PCR and PCR-RFLP techniques are now being used as a reliable way for detection of H pylori organism and clarithromycin resistance gene mutations, respectively.
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2015.Ge.P (Browse shelf(Opens below)) Not for loan 01010110068528000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.33.M.Sc.2015.Ge.P (Browse shelf(Opens below)) 68528.CD Not for loan 01020110068528000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine

Clarithromycin-based eradication therapy regimens represent the gold standard in management of H. pylori organism. Clarithromycin resistance is the main cause of failure of eradication therapy which may be due to multiple genetic mutations, single or combined together. Aim of work: Determining the prevalence and the genetic background of clarithromycin resistance of the H. Pylori strains isolated from gastric biopsies in Egyptian patients. Patients and methods : Gastric biopsies were obtained from 100 egyptian patients having upper gastrointestinal manifestations. Biopsies underwent PCR for detecting H pylori organism then PCR-RFLP to detect clarithromycin resistance. Results : H pylori was detected in 70 patients, of them, 35 cases were resistant to clarithromycin CONCLUSION : PCR and PCR-RFLP techniques are now being used as a reliable way for detection of H pylori organism and clarithromycin resistance gene mutations, respectively.

Issued also as CD

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