Carbetocin versus combination of oxytocin and ergometrine for the prevention of postpartum hemorrhage following cesarean section / Noha Yousry Ahmed Ahmed ; Supervised Gamal Gamal Eldin youssef , Hala Abdelwahab Abdellatef , Youssra Sameh lasheen

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics

Patients And Method: fifty primigravida women with gestational age more than 37weeks without any risk factors for postpartum haemorrhage undergoing elective or urgent caesarean section under regional were randomly divided into two equal groups: Group A: included 25 patients, they received Oxytocin 10 IU IV +ergometrine0.2 mg. Group B: included 25 patients, they received carbetocin, 100 mcg IV. The reason for administering additional uterotonic drugs in the oxytocin group (according to the operating obstetrician) was significantly more likely to be for PPH treatment. Results: The present study showed that results of comparison between two groups as comparing pre- and 24 hours post-operative hemoglobin (HB) between both groups results showed statistical significance in favoring of carbetocin group(p value <0.05) Again regarding estimated blood loss results are statistically significant. concerning maternal adverse effects in the form of elevated blood pressure there was statistical significance in which there was 28% elevation in the non carbetocin group. Again concerning nausea and vomiting they were significantly obvious in the non carbetocin group. Conclusion: combined intravenous carbetocin is effective to prevent atonic post-partum haemorrhage following cesarean section. It is as potent as combination of I.V syntocinon and ergometrine. In contrast with combination of syntocinon and ergometrine, carbetocin alone is one drug with less maternal adverse effects like elevated blood pressure, nausea and vomiting

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