Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

The prevalence of minimal hepatic encephalopathy (MHE) varies according to the diagnostic tool used in its detection. Many studies tested psychometric, neurophysiological tests and computerized tests however a standardized approach to the diagnosis of MHE is not yet available. The aim of our study is to evaluate the diagnosis of minimal hepatic encephalopathy (MHE) with critical flicker frequency (CFF). The study was conducted on 90 patients with liver cirrhosis of different causes and 30 healthy subject as control divided into 4 groups: Group 1(30) healthy individuals as a control group, group 2 (30) patients with liver cirrhosis child class B, Group 3(30) patients with liver cirrhosis child C and group 4(30) patients with overt HE, For all participants, critical flicker frequency were performed. CFF detected abnormality in 90% (81) of patients. Accuracy of CFF in differentiation of child B from normal is 100%, child C from normal is 100%, overt HE from normal is 100%, child B from child C is 80%, overt HE from child B is 100% and overt HE from child C is 100%

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