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One step microbial production of some steroidal drugs from progesterone / Heba Ahmed Ali Abdelrahman ; Supervised Abdelgawad M. Hashem , Abdelmonem H. Elrefai

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Heba Ahmed Ali Abdelrahman , 2014Description: 212 P. : charts ; 25cmOther title:
  • الخطوة الميكروبية الواحدة لإنتاج بعض العقاقير السترويدية من البروجسترون [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology Summary: The efficiency of nine different fungal species to produce 11Ü - hydroxyprogesterone from progesterone was investigated. The most active species Mucor racemosus produced 11Ü-HP output (54%) and two other transformation products. The transformation products were separated and characterized on the basis of their GC / MS analysis as 11Ü - hydroxyprogesterone (11Ü - HP) as main product (I); 4-pregnen- 18 - al - 11Ý, 21 - diol - 3,20 - dione (Aldosterone) (II) and 20 - hydroxy- 5Ü- pregnan- 18 - oic acid (III) as minor products. The effect of different media was also studied. The maximum bioconversion efficiency was recorded by a medium having the following composition (g / l): glucose, 20; peptone, 1; yeast, 1; KH₂PO₄, 0.74; MgSO₄.7H₂O, 1; L-asparagine, 0.7
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2014.He.O (Browse shelf(Opens below)) Not for loan 01010110064301000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2014.He.O (Browse shelf(Opens below)) 64301.CD Not for loan 01020110064301000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

The efficiency of nine different fungal species to produce 11Ü - hydroxyprogesterone from progesterone was investigated. The most active species Mucor racemosus produced 11Ü-HP output (54%) and two other transformation products. The transformation products were separated and characterized on the basis of their GC / MS analysis as 11Ü - hydroxyprogesterone (11Ü - HP) as main product (I); 4-pregnen- 18 - al - 11Ý, 21 - diol - 3,20 - dione (Aldosterone) (II) and 20 - hydroxy- 5Ü- pregnan- 18 - oic acid (III) as minor products. The effect of different media was also studied. The maximum bioconversion efficiency was recorded by a medium having the following composition (g / l): glucose, 20; peptone, 1; yeast, 1; KH₂PO₄, 0.74; MgSO₄.7H₂O, 1; L-asparagine, 0.7

Issued also as CD

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