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Comparative study on the acquired humoral immune response to Vi polysaccharide and other immune products for Salmonella typhi / Heba Mohamed Osama Elsayed Hassan Awad ; Supervised Alaa Eldien M. S. Hosny , Mohamed Reda Mohamed Diab , Rania Abdelmonem Mostafa Khattab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Heba Mohamed Osama Elsayed Hassan Awad , 2015Description: 123 P. : photographs ; 25cmOther title:
  • درا{uئإآ٣}{uئإ٩٤} {uئإإ٣}{uئإؤ٨}{uئإ٨إ}ر{uئإإ٧}{uئإ٩٤} {uئإؤئ}{uئإئأ}{uئإآ٣}{uئإ٩٨}{uئإء٠}{uئإ٨إ}{uئإ٩١}{uئإ٩٤} ا{uئإؤئ}{uئإإ٤}{uئإإ٨}{uئإ٨إ}{uئإأآ}{uئآئئ}{uئإ٩٤} ا{uئإؤئ}{uئإإ٤}{uئإؤأ}{uئإ٩٨}{uئإآ٤}{uئإ٩٢}{uئإ٩٤} و {uئإ٩٧}{uئإؤأ}{uئإإإ}{uئآئإ}{uئإإ٦} ا{uئإئ٧}{uئإ٩ئ}{uئإآ٤}{uئإ٨إ}م ا{uئإؤئ}{uئإإ٤}{uئإأ٠}{uئإ٨إ}دة {uئإؤئ}{uئإأأ}{uئإءء}{uئآئإ}{uئإءء} ا{uئإؤئ}{uئإآ٤}{uئإؤأ}{uئإءإ}{uئآئإ}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإء٤}{uئإءء}د {uئإؤئ}{uئإإ٤}{uئإءإ}{uئإآئ}{uئآئئ}{uئإ٩٤} {uئإإ٣}{uئآئئ}{uئإؤأ}{uئإءإ}وب {uئإإ٣}{uئإءإ}ض ا{uئإؤئ}{uئإ٩٨}{uئآئئ}{uئإؤ٤}{uئإإإ}د و {uئإؤئ}{uئإإ٤}{uئإإ٨}{uئإ٩٨}{uئإء٠}{uئإ٨إ}ت {uئإإ٣}{uئإإ٨}{uئإ٨إ}{uئإأآ}{uئآئئ}{uئإ٩٤} أ{uئإء٧}{uئإءإ}ى {uئإؤئ}{uئآءآ} [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology Summary: The efficacy of different vaccines, for Salmonella typhi, including Vi capsular polysaccharide (Vi - CPS), outer membrane protein (OMP) fraction, killed whole cell and the traditionally heat killed vaccine were compared. The level of antibodies after immunization of mice was estimated using the indirect whole cell ELISA technique; the whole cells as ''coating antigen'' were used and the sensitivity of the assay was enhanced significantly by in - situ heat treatment of the coating antigen rather than pre - heated coating antigen. Immunizing doses of Vi capsular polysaccharide, 2 and 4 æg given subcutaneously (S.C) and 4 æg given intraperitoneal (I.P), showed significant immune response. However, the response to these doses was almost similar without significant difference. Therefore, a subcutaneous dose of 2 æg is recommended. In general, the highest response was obtained using the OMP but its protection was reported to be reduced post infection with Vi - expressing Salmonella
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2015.He.C (Browse shelf(Opens below)) Not for loan 01010110067641000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2015.He.C (Browse shelf(Opens below)) 67641.CD Not for loan 01020110067641000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

The efficacy of different vaccines, for Salmonella typhi, including Vi capsular polysaccharide (Vi - CPS), outer membrane protein (OMP) fraction, killed whole cell and the traditionally heat killed vaccine were compared. The level of antibodies after immunization of mice was estimated using the indirect whole cell ELISA technique; the whole cells as ''coating antigen'' were used and the sensitivity of the assay was enhanced significantly by in - situ heat treatment of the coating antigen rather than pre - heated coating antigen. Immunizing doses of Vi capsular polysaccharide, 2 and 4 æg given subcutaneously (S.C) and 4 æg given intraperitoneal (I.P), showed significant immune response. However, the response to these doses was almost similar without significant difference. Therefore, a subcutaneous dose of 2 æg is recommended. In general, the highest response was obtained using the OMP but its protection was reported to be reduced post infection with Vi - expressing Salmonella

Issued also as CD

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