Prognostic value of microRNA-21/ Ki-67 in non-hodgkin`s lymphoma, Egypt / Hend Atteya Abbas Asker ; Supervised Lobna Ahmed Abdelazim Refaat , Hussein Mostafa Khaled , Reham Ahmed Rashed

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Hend Atteya Abbas Asker

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TextLanguage: English Publication details: Cairo : Hend Atteya Abbas Asker , 2019Description: 167 P. : charts , facsimiles ; 25cmOther title:

فى سرطان الغدد الليمفاوية الغير هودجكين K167 دور الأحماض النووية الريبوزية المتناهية الصغر 21 و البروتين النووى [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology Summary: MicroRNA-21 (MIR-21) is a small non-coding RNA that inhibits target genes expression thus affects tumorigenesis. Ki 67 is a nucleolar protein antigen in proliferating cells. Ki 67 expression is highly correlated with the proliferation rate. Immunohistochemical assay (IHC) of Ki67 antigen in paraffin section (Ki67 proliferative index) represents the active growth fraction of the tumor. We aim to evaluate the diagnostic and prognostic value of MIR-21 and Ki 67 as a potential biomarker of non- Hodgkin`s lymphoma (NHL) Methods: We prospectively enrolled 64 newly diagnosed B-NHL (DLBCL) patients (from May 2017 to 2018). Serum MIR-21 and tissue Ki 67 were assessed with RT- PCR and IHC of lymph node biopsy respectively. The primary outcomes were to identify overall survival (OS), and progression free survival (PFS), while the secondary outcomes were to identify the associations between different variables and MIR-21 and Ki 67. Spearman{u2019}s correlation was used and expressed as correlation coefficient (r). Kaplan-Meier survival curves were used and compared using log-rank. Cox regression was used to identify the independent predictors of survival

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.03.Ph.D.2019.He.P (Browse shelf(Opens below))		Not for loan		01010110080029000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.19.03.Ph.D.2019.He.P (Browse shelf(Opens below))	80029.CD	Not for loan		01020110080029000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology

MicroRNA-21 (MIR-21) is a small non-coding RNA that inhibits target genes expression thus affects tumorigenesis. Ki 67 is a nucleolar protein antigen in proliferating cells. Ki 67 expression is highly correlated with the proliferation rate. Immunohistochemical assay (IHC) of Ki67 antigen in paraffin section (Ki67 proliferative index) represents the active growth fraction of the tumor. We aim to evaluate the diagnostic and prognostic value of MIR-21 and Ki 67 as a potential biomarker of non- Hodgkin`s lymphoma (NHL) Methods: We prospectively enrolled 64 newly diagnosed B-NHL (DLBCL) patients (from May 2017 to 2018). Serum MIR-21 and tissue Ki 67 were assessed with RT- PCR and IHC of lymph node biopsy respectively. The primary outcomes were to identify overall survival (OS), and progression free survival (PFS), while the secondary outcomes were to identify the associations between different variables and MIR-21 and Ki 67. Spearman{u2019}s correlation was used and expressed as correlation coefficient (r). Kaplan-Meier survival curves were used and compared using log-rank. Cox regression was used to identify the independent predictors of survival

Issued also as CD

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