Evaluation of serum fetuin A, its relation to insulin resistance in children and adolescents with type 1 diabete / Hussien Mohamed Hussien Ismail ; Supervised Hend Mehawed Abdellatif Soliman , Radwa Ahmed Abdelhamed Shamma , Doaa Mohamed Abdou Mostafaa

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction:Type 1 diabetes mellitus (T1DM) is a complex chroniccondition of childhood resulting from gradual autoimmune destruction ofthe insulin producing pancreatic islet cells. Obesity is a well{u2010}known riskfactor for insulin resistance and adds to the difficulty of the managementof youth with T1DM. Higher Fetuin A levels are associated with insulin resistance and cardiometabolic risk factors ,including systolic blood pressure (BP), diastolic BP, dyslipidemia, and waist circumference, inobesechildren Aim of study: to determine the serum level of L-Fetuin and its relation toinsulinresistanceinchildrenandadolescentswithT1D. Patients and methods: This was a cross sectional study which includedsixty five (n=65) children diagnosed with T1D who were presented and followed up at Pediatric Endocrinology Department at Cairo University Children's Hospital from November 2020 to January 2021. All patientswere subjected to full history taking; clinical evaluation and laboratoryresults were obtained from files, in addition to serum level assessment ofL-Fetuin. Results: 40% of study group were hypertensive, about 40% of the studygroup were pubertal. 16.9% had signs of poor metabolic control in theform of limited joint mobility. Most of children (82.4%) in the presentstudy were poorly controlled as the mean HbA1c was 9.6±1.5. The meanvalue of estimated glucose disposal rate was 6.9±2.1 with median 7.2 and range between (1.7-10.7) .And 93.8% of diabetic patients were dyslipidemic. About (53.8%) had elevated L-Fetuin with the mean of serum L-Fetuin 671.4±290.8ug/ml

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