The effect of simvastatin gel in the treatment of intrabony defect in chronic periodontitis : Clinical, radiographic and immunohistochemical studies / Marwa Mohamed Tawfiq Ali Abdalqader ; Supervised Azza Ezz Elarab , Kareman Said Elsoudany , Mohamed Khalifa Zayet

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

The present study was conducted to evaluate the effect of simvastatin gel in the treatment of intrabony defect in chronic periodontitis. The study was designed as split mouth in ten patients. Surgical procedure of open flap debridement was performed at affected sites to enable access to the defect. Simvastatin gel was delivered in ten sites and placement of placebo gel was done other ten sites. Pocket depth, clinical attachment level, plaque index, gingival index, linear measurements and bone density were recorded. Samples of gingival crevicular were collected at base line, 3 and 6 months postsurgically. Filter paper was used in samples collection and the samples were analyzed using ELISA technique to evaluate the level of osteopontin on the studied group. The statistical analysis showed that there was significant difference between a simvastatin group and placebo group in probing pocket depth, clinical attachment level, and bone density at the end of the study. The changes in the level of osteopontin were insignificant with simvastatin group at different follow up period. However it was significantly elevated in placebo group at 6 months

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