Study on validity of lung injury predictive score (LIPS) in early detection of patients with ARDS and CRP as a prognostic marker for outcome in Egyptian population / Mohamed Elhady Ahmed ; Supervised Gamal Hamed , Suzi Fawzi , Khaled Toaima

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is an example of a critical care syndrome with limited treatment options once the condition is fully established. Despite improved understanding of pathophysiology of ALI, the clinical impacthas been limited to improvements in supportive treatment. On the other hand, little has been done on the prevention of ALI.The presence of clinical risk factors such as shock, pneumonia, sepsis and hypoalbuminemia is associated with high possibility for ARDS development. Several plasma biologic markers have predictive value for death, ventilator-free days, and duration of organ failure when considered as single biomarkers in large patient populations.These biologic markers reflect the complex pathogenesis of ALI/ARDS and include markers of inflammation and others. Our aim of this work was early identification of the onset of acute lung injury (ALI) at the time of hospital admission in critically ill patients, to assess the validity of lung injury predictive score (LIPS) for early identification of acute lung injury (ALI) in critically ill patients, to examine plasma level of C-reactive protein (CRP) in patients with acute lung injury (ALI) and its relationship to outcome and severity of illness

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