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Topical photodynamic therapy of ehrlich solid tumors using TMPyP loaded in ultradeformable nanopharmaceuticals / Maha Ahmed Mahmoud Farag ; Supervised Maha Fadel Mohamed , Doaa Ahmed Abdelfadeel

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Maha Ahmed Mahmoud Farag , 2020Description: 84 P. : charts , facimiles ; 25cmOther title:
  • المحملة فى مستحضرات النانو الصيدلية المرنة TMPyP الصلبة باستخدام مادة ال Ehrlichالعلاج الضوئى الديناميكى الموضعى لأورام [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applicatin in Medical Summary: Photodynamic therapy is a clinically approved procedure for the treatment of neoplastic and other non-malignant diseases. Meso-tetrakis(N-methyl-4- pyridyl)porphyrin (TMPyP) is a photosensitizing agent which has been used in many applications. However, the use of TMPyP topically is limited due to its hydrophilicity. To overcome this problem,TMPyP was loaded in ethosomes.Three ethosomal formulae (A), (B) and (C) were prepared and characterized. Preparation (A) was chosen to be used in the in vitro and in vivo study, having the greatest encapsulation efficiency, the smallest size and the highest cumulative release percentage.The results of in vitro permeation study revealed that the ethosomal TMPyP was superior to the drug in the free form with permeation flux (3.92 og cm⁻²h⁻¹). In the in vivo animal study done on Swiss albino mice, after 19 days of tumor implantation, the group treated with the ethosomal preparation showed significantly smaller tumor size (143.28 ± 13.2 mm³) compared to the group treated with the free TMPyP (219 ± 11.9 mm³). It showed also significant longer survival time (21 days) compared to that treated with the free drug (18.2± 1.2 days). Based on the obtained results, transdermal delivery of TMPyP was potentiated by incorporating it in ethosomes
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.M.Sc.2020.Ma.T (Browse shelf(Opens below)) Not for loan 01010110082725000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.24.03.M.Sc.2020.Ma.T (Browse shelf(Opens below)) 82725.CD Not for loan 01020110082725000

Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applicatin in Medical

Photodynamic therapy is a clinically approved procedure for the treatment of neoplastic and other non-malignant diseases. Meso-tetrakis(N-methyl-4- pyridyl)porphyrin (TMPyP) is a photosensitizing agent which has been used in many applications. However, the use of TMPyP topically is limited due to its hydrophilicity. To overcome this problem,TMPyP was loaded in ethosomes.Three ethosomal formulae (A), (B) and (C) were prepared and characterized. Preparation (A) was chosen to be used in the in vitro and in vivo study, having the greatest encapsulation efficiency, the smallest size and the highest cumulative release percentage.The results of in vitro permeation study revealed that the ethosomal TMPyP was superior to the drug in the free form with permeation flux (3.92 og cm⁻²h⁻¹). In the in vivo animal study done on Swiss albino mice, after 19 days of tumor implantation, the group treated with the ethosomal preparation showed significantly smaller tumor size (143.28 ± 13.2 mm³) compared to the group treated with the free TMPyP (219 ± 11.9 mm³). It showed also significant longer survival time (21 days) compared to that treated with the free drug (18.2± 1.2 days). Based on the obtained results, transdermal delivery of TMPyP was potentiated by incorporating it in ethosomes

Issued also as CD

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