Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

Neonatal sepsis is a leading cause of neonatal mortality in developing countries. Identification of the etiological agents of neonatal sepsis is essential for effective treatment. Out of 106 microbial isolates recovered blood cultures of neonatal sepsis patients, seventy (66.1 %) isolates of them were Gram positive bacteria, 31 (29.2 %) isolates were belonging to Gram negative bacteria and 5 (4.7%) isolates were belonging to Candida sp. Coagulase negative staphylococci (CONS) was the most common causative late onset neonatal septicemia (LOS), which reached to 43(40.6%) of total isolates, followed by Micrococcus, Enterobacter, coagulase positive staphylococci (COPS),Candida, Shigella, E. coli, Bacillus, Citrobacter and Klebsiella isolates, which reached to 13(12.2%), 11(10.4%), 10(9.4%), 7(6.6%), 5(4.7%), 5(4.7%), 4(3.7%),4(3.7%) and 4(3.7%), respectively. CONS isolates were highly resistant to various tested antibiotics compared to COPS. In addition, 50% of Staphylococcus isolates were resistant to aminoglycosides, IPM, glycopeptides and linezolid antibiotics, while 50% of enterobacterial isolates were resistant to glycopeptides, aminoglycosides, monobactam and tetracycline

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