Transforming growth factor beta and c reactive protein as markers of inflammation in acne patients and their relation to metabolic syndrome : A case control study / Mariam Mostafa Abdelhamid Sleem ; Supervised Nesrin Samir Elkholy , Marwa Ahmed Kamel , Zeinab Ahmed Mohamed Nour

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: Acne vulgaris is a chronic inflammatory and recurrent skin condition related to the pilosebaceous unit. Metabolic syndrome (MetS) was found to be closely related to different chronic inflammatory diseases as acne. Transforming growth factor beta (TGFÝ) is a multi-functional cytokine that may provide a new insight in the pathogenesis of Acne and MetS. Objective: Estimating TGFÝ (tissue and serum levels) and C-reactive protein (CRP) in acne patients and controls. Assessment of MetS criteria in acne patients in comparison to controls. Patients and methods: Thirty patients with moderate to severe acne and thirty age and sex matched healthy controls were eligible for the study. Serum and tissue TGFÝ were estimated by enzyme linked immunosorbent assay (ELISA).Candidates were subjected to laboratory estimation of CRP. Clinical and laboratory examinations to assess anthropometric data and various criteria of metabolic syndrome were undergone for all enrolled subjects. Results: Tissue TGFÝ rather than serum showed higher significant levels in acne patients in comparison to controls.Tissue TGFÝ levels were significantly higher in dyslipidemic patients. Only serum TGFÝ showed higher significant mean levels in obese and overweight patients and it was positively correlated to body mass index in patients. Neither CRP nor the criteria of metabolic syndrome showed a significant difference between patients and controls

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