Assessment of serum and tissue levels of IL-17 in lichen planus / Marwa Kadry Anwar ; Supervised Sara Bahaa Eldin , Dina Elsharkawy ,Olfat Shaker

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Marwa Kadry Anwar

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Material type: Text

TextLanguage: English Publication details: Cairo : Marwa Kadry Anwar , 2019Description: 113 P. : charts , facsimiles ; 25cmOther title:

تقييم مستوى الإنترلوكين 17 في الدم و الأنسجة مرض الحزاز [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Summary: Background: Lichen planus (LP) is a chronic inflammatorydisease affecting the skin, mucous membranes, scalp and nails. Interleukin (IL)-17 is a proinflammatory cytokine involved in the pathogenesis of several autoimmune and inflammatory disorders. Aim of work: To measure the serum and tissue levels of IL-17 in LP patients in comparison to controls, in order to assess the possible role of IL-17 in the pathogenesis of LP. Methods: This study included 30 LP patients and 30 age and sex matched healthy controls. Blood samples and skin biopsies were taken from all participants for evaluation of serum and tissue IL-17 levels by Enzyme linked immunosorbent assay (ELISA). Results: Serum and tissue IL-17 were significantly higher in patients than controls (p=0.000 for both). A statistically significant positive correlation was found between serum IL-17 and extent of the disease (r=0.584, p= 0.001)

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.M.Sc.2019.Ma.A (Browse shelf(Opens below))		Not for loan		01010110079073000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.10.M.Sc.2019.Ma.A (Browse shelf(Opens below))	79073.CD	Not for loan		01020110079073000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology

Background: Lichen planus (LP) is a chronic inflammatorydisease affecting the skin, mucous membranes, scalp and nails. Interleukin (IL)-17 is a proinflammatory cytokine involved in the pathogenesis of several autoimmune and inflammatory disorders. Aim of work: To measure the serum and tissue levels of IL-17 in LP patients in comparison to controls, in order to assess the possible role of IL-17 in the pathogenesis of LP. Methods: This study included 30 LP patients and 30 age and sex matched healthy controls. Blood samples and skin biopsies were taken from all participants for evaluation of serum and tissue IL-17 levels by Enzyme linked immunosorbent assay (ELISA). Results: Serum and tissue IL-17 were significantly higher in patients than controls (p=0.000 for both). A statistically significant positive correlation was found between serum IL-17 and extent of the disease (r=0.584, p= 0.001)

Issued also as CD

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