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Evaluation of the genetic polymorphisms rate of the tumor necrosis factor- alpha gene at positions -238 and -308 in the Egyptian hepatitis c virus patients / Marwa Nageh Abdelraouf Mahmoud ; Supervised M. Akmal Abdelraheim Elghor , Magda Mohmmed Noshy , Hanaa Ahmed Amer

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Marwa Nageh Abdelraouf Mahmoud , 2014Description: 118 P. : charts , facsimiles ; 25cmOther title:
  • تقييم معدل تعدد الاشكال المظهرية لجين عامل النخر الورمى الفا فى الموضعين -832 و -302 فى المرضى المصريين المصابين بالفيروس الكبدى الوبائى سى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: Tumor necrosis factor-alpha (TNF-Ü) is an important cytokine in generating an immune response against infection with hepatitis C virus (HCV). In HCV infection, the production of inappropriate cytokine levels may contribute to viral persistence. The G {uF0E0} A transition at position -308 and -238 in the TNF-Ü promoter has shown to affect the overall expression and the secretion of TNF-Ü. The aim of this study was to investigate the prevalence of genotypes associated with polymorphisms of TNF-Ü promoter at position -308 and -238 in a group of Egyptian HCV- infected patients compared with healthy uninfected control subjects. In addition, the association between these polymorphisms and the clinical characteristics of the positive HCV patients were investigated. Genotyping was determined by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP) on genomic DNA isolated from 61 HCV patients and 20 healthy uninfected control
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2014.Ma.E (Browse shelf(Opens below)) Not for loan 01010110065318000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2014.Ma.E (Browse shelf(Opens below)) 65318.CD Not for loan 01020110065318000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Tumor necrosis factor-alpha (TNF-Ü) is an important cytokine in generating an immune response against infection with hepatitis C virus (HCV). In HCV infection, the production of inappropriate cytokine levels may contribute to viral persistence. The G {uF0E0} A transition at position -308 and -238 in the TNF-Ü promoter has shown to affect the overall expression and the secretion of TNF-Ü. The aim of this study was to investigate the prevalence of genotypes associated with polymorphisms of TNF-Ü promoter at position -308 and -238 in a group of Egyptian HCV- infected patients compared with healthy uninfected control subjects. In addition, the association between these polymorphisms and the clinical characteristics of the positive HCV patients were investigated. Genotyping was determined by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP) on genomic DNA isolated from 61 HCV patients and 20 healthy uninfected control

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