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Retrospective study of extranodal non-hodgkin{u2019}s lymphoma : Response to treatment and factors affecting prognosis / Nafie Faisal Mohamed Makady ; Supervised Ehab Mostafa Elnakoury , Raafat Ragai Abdelmalek , Mennat Allah Mahmoud Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nafie Faisal Mohamed Makady , 2018Description: 91 P. ; 25cmOther title:
  • دراسة مرجعية عن ورم الغدد الليمفاوية (اكسترانودال) خارج الغدد الليمفاوية : الاستجابة للعلاج و العوامل المؤثرة فى مسار المرض [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology-Clinical Summary: This is a 10-year retrospective study on patients diagnosed with aggressive lymphoma in NEMROCK between 2008-2018. We investigated the effect of extranodal involvement and its effect on response and survival. Data of patients with aggressive lymphoma was collected from the NEMROCK database and analyzed. Out of 377 patients, 210 (55.7%) patients had extranodal involvement. The most common site involved was GIT followed by head and neck. Our study confirms that patients with extranodal involvement show worse OS, especially with GIT, bone marrow, skin/soft tissue, and CNS involvement. There was no significant difference in DFS between nodal and extranodal involvement. There was significant difference in response rate between nodal and extranodal group of patients after treatment with chemotherapy. This significant difference was eliminated after addition of rituximab to chemotherapy. Patients with bulky lymph nodes (>7.5 cm) showed significantly worse response rates and survival. Only 4.9% of patients developed CNS relapse. Our results showed that there is significant association between extranodal involvement of the head/neck and skin/soft tissue with CNS relapse
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2018.Na.R (Browse shelf(Opens below)) Not for loan 01010110077368000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.23.M.Sc.2018.Na.R (Browse shelf(Opens below)) 77368.CD Not for loan 01020110077368000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology-Clinical

This is a 10-year retrospective study on patients diagnosed with aggressive lymphoma in NEMROCK between 2008-2018. We investigated the effect of extranodal involvement and its effect on response and survival. Data of patients with aggressive lymphoma was collected from the NEMROCK database and analyzed. Out of 377 patients, 210 (55.7%) patients had extranodal involvement. The most common site involved was GIT followed by head and neck. Our study confirms that patients with extranodal involvement show worse OS, especially with GIT, bone marrow, skin/soft tissue, and CNS involvement. There was no significant difference in DFS between nodal and extranodal involvement. There was significant difference in response rate between nodal and extranodal group of patients after treatment with chemotherapy. This significant difference was eliminated after addition of rituximab to chemotherapy. Patients with bulky lymph nodes (>7.5 cm) showed significantly worse response rates and survival. Only 4.9% of patients developed CNS relapse. Our results showed that there is significant association between extranodal involvement of the head/neck and skin/soft tissue with CNS relapse

Issued also as CD

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